Aberrantly Low Transferrin Receptor Expression on Human Monocytes Is Associated with Nonpermissiveness for Legionella pneumophila Growth
Identifieur interne : 002474 ( Main/Exploration ); précédent : 002473; suivant : 002475Aberrantly Low Transferrin Receptor Expression on Human Monocytes Is Associated with Nonpermissiveness for Legionella pneumophila Growth
Auteurs : Thomas F. Byrd [Niger, États-Unis] ; Marcus A. Horwitz [États-Unis]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2000.
Abstract
Growth of Legionella pneumophila within human monocytes is iron dependent. A person with monocytes uniquely nonpermissive to L. pneumophila growth was identified whose monocytes expressed an abnormally low number of transferrin receptors in the nonactivated state, similar to the typically low level expressed in the interferon-γ—activated state. The monocytes failed to up-regulate transferrin receptor expression appropriately in response to iron-transferrin. After treatment for chronic periodontal disease, the subject's monocytes converted to a permissive state. In contrast to the nonpermissive state, the permissive monocytes had normal transferrin receptor expression and up-regulated transferrin receptor expression appropriately in response to iron-transferrin. Thus, a nonpermissive state for L. pneumophila intracellular multiplication is associated with low levels of transferrin receptor expression in nonactivated monocytes and with an inability to up-regulate transferrin receptor expression in response to iron-transferrin. This nonpermissive state may be related to chronic inflammatory conditions such as periodontal disease.
Url:
DOI: 10.1086/315390
Affiliations:
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Byrd</name><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Niger</country></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Nouveau-Mexique</region></placeName><wicri:cityArea>Reprints or correspondence: Dr. Thomas F. Byrd, Dept. of Medicine (111J), Albuquerque VA Medical Center, 1501 San Pedro S.E., Albuquerque</wicri:cityArea></affiliation></author><author><name sortKey="Horwitz, Marcus A" sort="Horwitz, Marcus A" uniqKey="Horwitz M" first="Marcus A." last="Horwitz">Marcus A. Horwitz</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Division of Infectious Diseases, Department of Medicine, School of Medicine, University of California</wicri:orgArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="2000-04">2000</date><biblScope unit="vol">181</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="1394">1394</biblScope><biblScope unit="page" to="1400">1400</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Growth of Legionella pneumophila within human monocytes is iron dependent. A person with monocytes uniquely nonpermissive to L. pneumophila growth was identified whose monocytes expressed an abnormally low number of transferrin receptors in the nonactivated state, similar to the typically low level expressed in the interferon-γ—activated state. The monocytes failed to up-regulate transferrin receptor expression appropriately in response to iron-transferrin. After treatment for chronic periodontal disease, the subject's monocytes converted to a permissive state. In contrast to the nonpermissive state, the permissive monocytes had normal transferrin receptor expression and up-regulated transferrin receptor expression appropriately in response to iron-transferrin. Thus, a nonpermissive state for L. pneumophila intracellular multiplication is associated with low levels of transferrin receptor expression in nonactivated monocytes and with an inability to up-regulate transferrin receptor expression in response to iron-transferrin. This nonpermissive state may be related to chronic inflammatory conditions such as periodontal disease.</div></front></TEI><affiliations><list><country><li>Niger</li><li>États-Unis</li></country><region><li>Californie</li><li>Nouveau-Mexique</li></region><settlement><li>Los Angeles</li></settlement></list><tree><country name="Niger"><noRegion><name sortKey="Byrd, Thomas F" sort="Byrd, Thomas F" uniqKey="Byrd T" first="Thomas F." last="Byrd">Thomas F. Byrd</name></noRegion></country><country name="États-Unis"><region name="Nouveau-Mexique"><name sortKey="Byrd, Thomas F" sort="Byrd, Thomas F" uniqKey="Byrd T" first="Thomas F." last="Byrd">Thomas F. Byrd</name></region><name sortKey="Horwitz, Marcus A" sort="Horwitz, Marcus A" uniqKey="Horwitz M" first="Marcus A." last="Horwitz">Marcus A. Horwitz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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